Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.
نویسندگان
چکیده
Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The calcium silicate shell traps and protects an siRNA payload, which can be delivered to neuronal tissues in vitro or in vivo. Gene delivery is enhanced by the action of targeting and cell-penetrating peptides attached to the calcium silicate shell.
منابع مشابه
Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain†
The delivery of therapeutics based on RNA interference to diseased or damaged tissues in the body is a significant challenge, and the privileged tissues of the brain are among the most difficult to target. By encapsulating the RNA-based therapeutic within a hollow silicon nanoparticle coated with a thin shell of graphene oxide, the sensitive oligonucleotide can be protected from in vivo degrada...
متن کاملHighly efficient siRNA delivery from core-shell mesoporous silica nanoparticles with multifunctional polymer caps.
A new general route for siRNA delivery is presented combining porous core-shell silica nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the internal storage and release of siRNA from mesoporous silica nanoparticles (MSN) with orthogonal core-shell surface chemistry was investigated as a function of pore-size, pore morphology, surface properties and pH. Very ...
متن کاملGlucan Particles for Macrophage Targeted Delivery of Nanoparticles
Glucan particles (GPs) are hollow, porous 2-4 μm microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-β-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. GPs have been used for macrophage-targeted delivery of soluble payloads (DNA, siRNA, protein, and small molecules) encapsulated inside the hollo...
متن کاملDesign and performance investigation of electrospun PVA nanofibers containing core-shell nanostructures for anticancer drug delivery
Objective: The purpose of this work was design and performance investigation of a nanocarrier based on magnetic nanofibers containing core-shell nanostructuresfor anticancerdrug delivery of daunorubicin (DAN) by measuring their drug release at different pH values. Methods: Fe3O4 nanoparticles and Fe3O4@SiO2core-shell nanostructures were synthesized through coprecipitation and Stöber methodresp...
متن کاملEGFP-EGF1-Conjugated PLGA Nanoparticles for Targeted Delivery of siRNA into Injured Brain Microvascular Endothelial Cells for Efficient RNA Interference
Injured endothelium is an important target for drug and/or gene therapy because brain microvascular endothelial cells (BMECs) play critical roles in various pathophysiological conditions. RNA-mediated gene silencing presents a new therapeutic approach for treating such diseases, but major challenge is to ensure minimal toxicity and target delivery of siRNA to injured BMECs. Injured BMECs overex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Advanced materials
دوره 28 36 شماره
صفحات -
تاریخ انتشار 2016