Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.

نویسندگان

  • Jinyoung Kang
  • Jinmyoung Joo
  • Ester J Kwon
  • Matthew Skalak
  • Sazid Hussain
  • Zhi-Gang She
  • Erkki Ruoslahti
  • Sangeeta N Bhatia
  • Michael J Sailor
چکیده

Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The calcium silicate shell traps and protects an siRNA payload, which can be delivered to neuronal tissues in vitro or in vivo. Gene delivery is enhanced by the action of targeting and cell-penetrating peptides attached to the calcium silicate shell.

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عنوان ژورنال:
  • Advanced materials

دوره 28 36  شماره 

صفحات  -

تاریخ انتشار 2016